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Association between neuropeptide Y gene polymorphisms and alcohol dependence: a case-control study in two Author Manuscript indpendent populations. European Addiction Research.

A preclinical model for identifying rats at risk of alcohol use disorder

Mammalian Genome. Gene, Environment Association Studies Consortium, A genome wide association study of alcohol dependence. Page 33 administration in Sprague-Dawley rats. Reduced alcohol consumption in mice lacking preprodynorphin. Voluntary ethanol intake in the rat: effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment.

European Journal of Pharmacology. Prolactin activates mitogen- activated protein kinase signaling and corticotropin releasing hormone transcription in rat hypothalamic neurons. Effect of topiramate treatment on ethanol consumption in rats. Ethanol directly excites dopaminergic ventral tegmental area reward neurons. Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro.

Brain Research. Serotonin potentiates ethanol-induced excitation of ventral tegmental area neurons in brain slices from three different rat strains. Journal of Pharmacology and Experimental Therapeutics. Psychostimulant users are sensitivie to the stimulus properties of alcohol as indexed by alcohol-induced cardiac reactivity. Psychology of Addictive Behavior.

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Individual differences underlying susceptibility to addiction: role for the endogenous oxytocin system. Pharmacology, Biochemistry and Behavior. Use of M1—M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system.

Neurochemistry Research. Author Manuscript Cadoret, RJ. Familial transmission of psychiatric disorders associated with alcoholism. In: Begleiter, H.


The Genetics of Alcoholism. Nicotinic excitation of rat ventral tegmental neurones in vitro studied by intracellular recording. Distribution of corticotropin releasing hormone receptor immunoreactivity in the rat hypothalamus: coexpression in neuropeptide Y and dopamine neurons in the arcuate. Associations of the 5-hydroxytryptamine serotonin receptor 1B gene HTR1B with alcohol, cocaine, and heroin abuse.

Association of the HTR2A gene with alcohol and heroin abuse. Human Genetics. Microinjections of phencyclidine PCP and related drugs into nucleus Author Manuscript accumbens shell potentiate medial forebrain bundle brain stimulation reward.

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A quantitative trait locus for alcohol consumption in selectively bred rat lines. The interaction of smoking, environment and heredity and their implications for disease aetiology: a report of epidemiological studies on the Swedish twin registries. Acta Medica Scandinavia. Chronic ethanol exposure potentiates NMDA excitotoxicity in cerebral cortical neurons. Journal of Neurochemistry. New perspectives on catecholaminergic regulation of executive circuits: evidence for independent moduation of prefrontal functions by midbrain dopaminergic and noradrenergic neurons.

Frontiers in Neural Circuits. Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders.


Gene Editing Makes Mice Cocaine-Proof | Technology Networks

Single- Author Manuscript nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene CRHR1 are associated with quantitative trait of event-related potential and alcohol dependence. Association of single nucleotide polymorphisms in a glutamate receptor gene GRM8 with theta power of event- related oscillations and alcohol dependence. Drinking patterns and problems in emergency services in Poland. Alcohol and Alcoholism.

Acoustic startle reactivity during acute alcohol withdrawal in rats that differ in genetic predisposition toward alcohol drinking: effect of stimulus characteristics. Individual vulnerability to escalated aggressive behavior by a low dose of alcohol: Decreased serotonin receptor mRNA in the prefrontal cortex of male mice.

Genes Brain and Behavior.

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    Behavioral Neuroscience. Author Manuscript Cooper, JR. Biochemical Basis of Neuropharmacology. Cosgrove KP. Imaging receptor changes in human drug abusers. Current Topics in Behavioral Neuroscience. Cotton NS. The familial incidence of alcoholism. Journal of Studies on Alcohol.